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$ aws s3 ls

Could not connect to the endpoint URL: "https://s3.us-east-1a.amazonaws.com/"

You probably have something wrong in your default profile for the default region.

Check your file at ~/.aws/config, you have something like

[default]
region=us-east-1a
...

Fix the region to region=us-east-1 and then the command will work correctly

AWS S3 CLI – Could not connect to the endpoint URL