There are two ways:
1. Delete this file
/system/library/usereventplugins/applehidhouseagent.plugin/contents/macos/appleh idmouseagent

2. The terminal uses the following commands:
CD/system/library/usereventplugins
sudo MV com.apple.cts.plugin com.apple.cts.plugin.disabled
sudo shutdown – r now

The second solution I used has been solved

Mac operation not permitted

It is found that El Capitan (10.11) has joined the rootless mechanism, and many system directories can no longer read and write at will, even if the root permission is set

The following paths cannot be written and executed

/System

/bin

/sbin

/usr (except /usr/local)

Join this mechanism is mainly to prevent the invasion of malicious programs, more we can see the official website

https://developer.apple.com/videos/play/wwdc2015/706/

How to close

Restart and press Command + R to enter recovery mode and open terminal

csrutil disable

How to open

Restart and press Command + R to enter recovery mode and open terminal

csrutil enable